 Systemic sclerosis is a rare, complex connective tissue disease with high mortality and no specific treatment, characterized by vascular disease, auto-antibody production, inflammation, and fibrosis, and may be related to a polarization of the immune response towards the TH-17 pathway, which involves cytokines such as IL-17A, IL-21, and IL-22. This article was authored by Rafaela Silva-Gimárez-Goncalvez, Michele C. Pereira, Andrea Tavares-Dantas, and others.