 The newly emerged coronavirus disease 2019, COVID-19, caused by severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, was first reported in Wuhan, China, and has since rapidly spread around the world. Some COVID-19 patients have experienced a severe symptom of acute respiratory distress syndrome, ARDS, with high mortality. This high severity is due to a cytokine storm, which is triggered by the hyperactivation of the interleukin-6, Illinois-6, amplifier, which regulates the nuclear factor CAPA-B, NFB, pathway and stimulates the simultaneous activation of Illinois-6, signal transducer and activator of transcription-3, STAT-3, and NFB signaling in non-immune cells such as alveolar epithelial cells and endothelial cells. We hypothesize that Illinois-6, STAT-3 signaling may be a promising therapeutic target for the cytokine storm in COVID-19 patients, as Illinois-6 is a major STAT-3. This article was authored by Shintaro Hogyo, Mona Uchida, Kumiko Tanaka, and others. We are article.tv, links in the description below.