 Polylactic acid, PLA, is a popular biomaterial used in dentistry due to its biocompatibility, biodegradability, and nontoxicity. It is commonly used in dental models, therapeutics, and tissue engineering. Fused filament fabrication, FFF, or Fused Deposition Modeling, FDM, is a widely used additive manufacturing, AM, technique to produce complex and functional geometries directly from CAD files. This review discusses the current challenges and future perspectives of PLA in dentistry with FFF. Suggestions are made for future directions to extend to more dental applications, including support structures and lattice structures, as well as considering additional criteria such as sustainability and uncertainty. Machine learning, ML, techniques may be used to reduce the number of failed cases when using PLA in dentistry with FFF. This article was authored by Geis Karmanda. We are article.tv, links in the description below.