 Diabetic nephropathy, DN, is the most common cause of kidney failure among people with diabetes. Recent research has suggested that certain gases, including nitric oxide, NO, carbon monoxide, CO, and hydrogen sulfide, H2S, may play a role in the development and progression of DN. These gases can interact with the extracellular matrix, ECM, and other proteins to affect cell function. This review provides an overview of the current knowledge about how these gases influence DN and discusses potential therapeutic strategies for treating DN using gasotransmitters. This article was authored by Sibir Kumar Jewin, Rosemary Auseff, Dibson Diab Gundam, and others.