 P22 virus-like particles, VLPs, can be used to create nanoreactors that increase the efficiency of multi-step biocatalysis by channeling substrates. These particles contain enzymes and cofactors that are bound together within the particle, allowing for faster reaction times than if they were free in solution. Additionally, the particles can be designed to have specific functions depending on the type of reaction desired. This article was authored by Yan Wang, Ekaterina Salivanovich, and Trevor Douglas.