 In anemia associated with a nomocytic picture, the first consideration would be that there isn't an underlying cytoplasmic delay in maturation or there may be an underlying cytoplasmic delay in maturation that is subtle and balanced out by a nuclear maturation delay. Anemia of chronic disease usually presents as a nomocytic anemia. The reason being that the RBC, the red blood cell count is reduced. The total hemoglobin is reduced but in the face of normal stages of maturation of both cytoplasm and nucleus. And so you're going to see a normal distribution curve except you would notice the reduced total hemoglobin and the reduced total number of red blood cells drawing attention to the fact that there is reduced cellular output from the bone marrow. In other words, the factory is not producing the amount that you expect rather than an abnormality in quality. So it's an abnormality in quantity.