 This review evaluates laboratory and clinical studies on biosyramic-based root canal sealers in endodontics. Biosyramic-based sealers have been found to be biocompatible and comparable to other commercial sealers. However, the clinical outcomes associated with their use are not well established in the literature. This article was authored by F.A.L. Haddad and Z.H.A.A.B Aziz.