 This study found that concurrent administration of low flow nasal oxygen, LFNO, with a mouthpiece and aerosol holding chamber increases the amount of medication inhaled into the lungs, while concurrent high flow nasal oxygen, HFNO, does not. Additionally, this study showed that adding LFNO or HFNO did not increase the level of aerosol particles in the test room. This article was authored by Barry Murphy, Mark McDiola-Ian, Mary Joyce, and others.