 So thank you very much for the award of this research gift and with a focus on pediatric nerve and muscle diseases as a clinician and a researcher I witnessed first hand the impact of muscle weakness, disability and shortened life expectancy in children with inherited nerve and muscle disorders and in fact many people in this room wouldn't be familiar with such disorders as spinal musculatrophy which is one of the most common that I would see is the leading inherited genetic cause of infant death. The treatment landscape has recently been transformed with the availability of the first and only treatment for spinal musculatrophy which is a form of motor neuronesies affecting children and what that has really shown is that there are so many more uncertainties now we have a treatment and prospects for future care so this research gift is fundamentally linked to the goals of the Brain Foundation in focusing on treatment, improving understanding of diseases treatment mechanisms to improve the treatment that we deliver to our patients to improve their outcomes. So essential to ongoing treatment in neuropathy and future developments is the availability of tissues and human biospecimens and amongst all these disorders it's absolutely essential to establish the research infrastructures to ensure that collection of such tissues is of high quality that it can be used for the best possible research in the future and to be able to manage the high quality samples and link it to high quality clinical data. So this study will be used to implement the research infrastructure to be able to establish such a bank for specimens and this will be very important in applying the new technologies across neuroscience research to be able to understand the mechanisms of disease the mechanisms of treatment and how to measure the success of such ones to be able to improve treatments and really apply innovative technologies and really expands the capacity for research across pediatric nerve diseases in the future so it is deeply appreciated and I think it will be a legacy for many years to come thank you.