 This systematic review found that Desmet's membrane endothelial keratoplasty DMEK performed in combination with either pre-operative or post-operative cataract surgery resulted in similar gains in visual acuity when compared to DMEK alone. Rebubbling rates and graft detachments were higher in the DMEK plus cataract surgery group, but there was no significant difference in graft rejection, survival rates or endothelial cell loss. This article was authored by Ritika Mukhija, Kristen Hene, Humbine Lee and others.