 Inflammation of central nervous system, CNS, is usually associated with trauma and infection. Neuro inflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuro inflammation is considered to have beneficial effects whereas chronic neuro inflammation can be harmful. In an immune system consisting of pattern recognition receptors, macrophages, and complement system plays a key role in CNS homeostasis following injury and inflection. Here we discuss how innate immune components can also contribute to neuro inflammation and neurodegeneration. This article was authored by Apishek Shostri, Domenico Marco Bonafati and Eide Kishore.