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Published on Aug 28, 2015
In this video and the accompanying Cell paper, the Tony Hyman and Simon Alberti groups at Max Planck Institute propose an interesting idea that aging cells fail to maintain the liquid phase of ALS-associated protein FUS. The FUS liquid compartment instead forms disease-link solid phase aggregation.
Avinash Patel, Hyun O Lee, Louise Jawreth, Shovamayee Maharana, Marcus Jahnel, Marco Y. Hein, Stoyno Stoynov, Julia Mahamid, Shambaditya Saha, Titus M. Franzmann, et al. (2015). A Liquid to Solid Phase Transition of the ALS Protein FUS Correlates with Disease. Cell 162.