 The prevalence of food allergies and anaphylaxis in children is increasing worldwide, with cows milk, hens eggs, and wheat allergies having a better prognosis than peanuts, tree nuts, and sea food allergies. Recent studies have identified factors affecting the natural course of food allergy, including symptom severity, age at diagnosis, comorbidities, skin prick, test reaction size, sensitization degree, IgA epitope specificity, diet, gut microbiome, and interventions such as immunotherapy. Clinicians should provide relevant knowledge on the natural course of food allergy to patients and caregivers, evaluate its resolution, and offer therapeutic options whenever possible. This article was authored by Kim Baek Jong and Su Yeon Lee.