 Factor V. Leiden and Prothrombin G20210A are two of the most common inherited thrombophilic disorders. They have been associated with increased risk of venous thromboembolism but their relationship with arterial thrombotic events, especially coronary ones, remains unclear. We conducted an extensive review of the existing literature to provide updated knowledge about the association between these two mutations and acute myocardial infarction. F. V. Leiden and Prothrombin G20210A screening should be implemented only in select cases, such as acute coronary syndrome in young individuals and or in the absence of traditional cardiovascular risk factors and or in the absence of significant coronary artery stenosis at angiography. Genetic counseling of family members of affected cases should also be done to ensure proper prevention measures. Extended Dual Anti-Platelet Therapy, DAPT, may be considered due to the lower risk of bleeding associated with F. V. Leiden. This article was authored by Minerva Kudruvidescu, Lacrimura Ayala Buneriu, Alexandra Dan Kostek, and others. We are article.tv, links in the description below.