 This paper examines the potential of a new cannabinoid derivative, hexahedral cannabinole, HHC, to be used as a recreational drug. It discusses the synthesis of the compound, its pharmacological properties, and its presence in commercial cannabis samples. The authors found that HHC is a potent cannabinoid agonist, but its presence in commercial cannabis samples was low. This suggests that HHC may be produced artificially or naturally in small amounts, but further research is needed to determine its exact role in cannabis consumption. This article was authored by Fabiana Russo, Maria Angela Vandeli, Giuseppe Biagini, and others.