 The spatial organization of chromosomes plays a key role in determining how genes are expressed. Two recent methods have been developed to study this phenomenon, both of which involve analyzing the spatial arrangement of genes within a cell. One method involves using super-resolution microscopy to observe the arrangement of chromatin in fixed cells, while the other uses fluorescence to track the movement of nascent INA molecules as they form into mature messenger INAs. Both methods found that genes tend to cluster together in close proximity, suggesting that physical proximity may be important in controlling gene expression. Additionally, the researchers found that genes located closer together were more likely to express simultaneously than those further apart. This suggests that physical proximity may play a role in coordinating gene expression. This article was offered by Christopher H. Bohrer and Daniel Larson.