 This study investigated the effectiveness of a multi-grip hand prosthesis under both direct and pattern recognition control. The results showed that participants who used pattern recognition control had significantly improved outcomes on the ACMC outcome measure compared to those who used direct control. Furthermore, offline analysis of calibration data indicated that EMG signal quality was sufficient to provide users with control performance at or better than direct control. This article was authored by an M. Simon, Christy L. Turner, Laura A. Miller and others.