 Nanoparticle-based co-delivery systems have been developed to address the challenges associated with delivering multiple drugs simultaneously. These systems can be designed to enhance targetability, increase internalization, and reduce cytotoxicity. The review article discussed the advantages of using uniform surface hybrid particles compared to anisotropic asymmetric particles. Uniform surface hybrids are typically composed of core shell particles, while anisotropic asymmetric particles include Janus, multi-compartments, and patchy particles. Homogenous or heterogeneous particles with specific characteristics can be used to deliver multiple cargoes, potentially improving the efficacy of treatments for diseases like cancer. This article was authored by DeLarum Cargari-Agnione and Sepida Kohi.