 Cancer metastasis is the spread of cancer cells from the original tumor to other parts of the body. It is responsible for most cancer deaths, accounting for approximately 90% of all cancer deaths. Early detection and growth inhibition of the primary tumor have led to significant improvements in overall survival rates, but limited progress has been made in treating metastasis. Chemotherapy and radiation therapies are currently used to treat metastatic cancer, but newer generations of anti-cancer drugs such as neutralizing antibodies and small molecule kinase inhibitors also show promise in reducing metastasis. Metastasis begins when cancer cells break away from the primary tumor and enter the bloodstream or lymphatic system. From there, they travel to distant organs where they settle and grow into secondary tumors. During this process, metastatic cells must undergo detachment, migration, invasion, and adhesion. These processes are influenced by multiple biochemical factors and interactions within the tumor microenvironment. Targeting these factors and interactions may provide opportunities for preventing and inhibiting metastasis. This article was authored by Xiang Mingguan. We are article.tv. Links in the description below.