 And then there's this term called the first pass effect, which means that when a medication is administered by the oral route and it passes through the liver, it is biotransformed or metabolized to such a high degree that there's not enough drug concentration left in the bloodstream after it goes through the liver to have the desired effect that we're trying to achieve with the medication. And so that only happens for oral medications. And so if we know that medications have a high first pass effect, then usually we have to think about other routes of administration besides an enteral route or a GI route that will allow to kind of bypass this first pass effect where the liver takes away some of that medication effectiveness.