 Transcranial temporal interference stimulation, TTIS, is a new type of neuromodulation technology that uses a sine wave potential generated by a DDS to stimulate the brain. This technology can be used to treat various neurological disorders such as Parkinson's disease, epilepsy and depression. The proposed TTIS device consists of a DDS, a current transformer and a current amplifier. In vitro experiments showed that the error percentage of the stimulation currents was less than 2%, indicating that the device works well. In vivo measurements also confirmed that the two pole configuration provides better cortical targeting than the four pole configuration. Finally, a pilot animal experiment showed that the two pole TTIS successfully activates the primary motor cortex in rats. These results suggest that the proposed TTIS device is safe and effective for neuromodulation. This article was authored by Zhao Zhong, Borshing Lin, Chunwei George Wu, and others. We are article.tv, links in the description below.