 Welcome to the second part of our pre-filled syringe seminar. My name is Klaus Ulher. I'm a Senior Product Manager at Syndagon Technology in Kreuzheim, Germany. Last video I have explained to you how the Ventube Stoppering works. But sometimes the Ventube Stoppering is not the appropriate method. For example, when you have a coated stopper or if you want to have a minimized air bubble in your syringe or if you want to have a minimum of oxygen in your syringe. Here you see the elements again, the syringe, the stopper and the rod. And this time we have instead of the Ventube a vacuum chamber. And now I will explain to you how the process works. The stopper is pushed by the rod into the vacuum chamber. Then the vacuum is applied between the stopper and the fill level. As soon as the right vacuum pressure is reached, the rod pushes the stopper into the syringe and due to the vacuum, the stopper will go down on the fill level. Here you see the vacuum and how the stopper is going down on the fill level. So if you find this video helpful, please subscribe our channel and write in the comments what you want to learn more in the future. Thank you.