 Primary focal segmental glomerulosclerosis, FSGS, is a rare form of kidney disease characterized by progressive scarring of the kidneys. It is one of the most common causes of nephrodic syndrome in children and young adults. This study examined the clinical and pathological characteristics of FSGS in Pakistani adults. The results showed that collapsing variant was the second most common variant after non-specific FSGS, which differs from previous reports from other regions. Additionally, the study found that arteriolopathy and fibrointimal thickening of arteries were more frequent than previously reported. This article was authored by Shahira Shaquille, Muhammad Mubarak, Javed Iqazi, and others.