 There are certain things that can exacerbate a sickle cell crisis, and those are usually extremes of temperature, and that is heat as well as cold, high altitudes because low oxygen exists in those high altitudes. Any kind of constrictive clothing or jewelry can preclude a crisis, as well as infections, so we need to make sure we educate our patients about infection prevention, and then pregnancy makes the patient more highly at risk for developing a sickle cell crisis because pregnancy causes more an increase in blood volume in the woman, and then also dehydration is a major cause for causing sickle cell crisis. Please head over to YouTube to check out my full video on sickle cell disease.