 tumor cells can become resistant to targeted therapies due to their ability to switch between different phenotypes. This process is known as tumor cell plasticity and involves several mechanisms, including epigenetic changes, gene expression alterations, and signaling pathway modulations. Targeted therapies can be combined with other treatments to overcome tumor cell plasticity and improve patient outcomes. This article was authored by Zhengyuosha, Ku and Pang, Zhuzan Wu, and others.