 18-FFDG Peru Time-slash-Central Time-scanners with a long axial field of view, Lafave, can provide increased sensitivity by reducing injected activity or shortening acquisition time. This study evaluated the limitations of reduced 18-FFDG activity doses on image quality, lesion detectability, and quantification of lesion uptake in the Biograph Vision Quadra, as well as assessed the benefits of the ultra-high sensitivity mode in a clinical setting. The results showed that reducing the activity to 0.5 MBQ-slash-KG-HS-slash-UHS in a Lafave Peru Time-slash-Central Time provides diagnostic image quality without statistically significant changes in uptake parameters, and the UHS mode improves image quality, noise, and lesion detectability compared to the HS mode. This article was authored by Eduardo Calderon, Fabian P. Schmidt, Wenholm-Lahn, and others.