 For major clades of Candida auris have been described, and all infections have clustered in these four clades. We identified an isolate representative of a potential fifth clade, separated from the other clades by greater than 200,000 single nucleotide polymorphisms, and a patient in Iran who had never traveled outside the country. This article was authored by Nancy E. Chow, Thundegrut, Hamid Badali, and others.