 Liposomes have been studied extensively as potential carriers for hydrophilic and hydrophobic drugs. They can be used for a variety of applications such as cancer treatment, antimicrobials, immunomodulators, diagnostics, ophthalmics, vaccines, enzymes, and genetic elements. However, liposomes face several challenges when it comes to drug delivery, including preparation methods, size, stability, and targeting. To address these issues, researchers have developed a new generation of liposomes with improved characteristics. This article was authored by Mehran Alavi, Nazer Karimi, and Masan Safai.