 Integrins are a family of transmembrane receptors that link the extracellular matrix to the cytoskeleton, allowing for cell adhesion, migration, signal transduction, and gene transcription. They play a key role in tumorigesis by promoting tumor growth, invasion, angiogenesis, metastasis, and drug resistance. Recent research has shown that they are overexpressed or activated in human hepatocellular carcinoma, HCC, and that they may be targeted for therapeutic intervention. This review summarizes the current understanding of the role of integrins in HCC, with particular focus on their expression, activation, and signalling pathways. It also updates the clinical, and pre-clinical studies of integrin-targeted drugs in the treatment of HCC. This article was authored by Chiung GAO, Jaolin Sun, Diu Fang, and others.