 The SMART study has been collecting data on antimicrobial resistance patterns in grand-negative bacteria from intraabdominal infections and urinary tract infections since 2002 and 2009 respectively. Over the past decade, the study has observed increasing resistance to carbapenems and extended spectrum beta-lactams, ESBLs. These findings have provided valuable insight into the prevalence of resistant strains and their susceptibility to various antibiotics. Additionally, the study has helped inform regulators about appropriate breakpoints for antibiotic susceptibility testing and has been used as a reference point for clinicians when prescribing antibiotics. This article was authored by Douglas Biedenbach, Stephen Hauser, Meredith Hackel, and others.