 Insulin resistance is a critical pathophysiological process in the onset and progression of type 2 diabetes mellitus. Obesity and lack of physical activity are the main contributing factors to this global epidemic. Alterations in the metabolism of lipids and excessive fat storage can lead to insulin resistance, which is a major cause of type 2 DM. Dietary changes and regular exercise are key components in prevention and treatment of type 2 DM. Fish oil and other sources of omega-3 polyunsaturated fatty acids, pufas, are known to reduce inflammation and improve insulin sensitivity. These fatty acids also help regulate cellular processes involved in mitochondria function and energy production, which can protect against insulin resistance. This article was authored by Susmita Sinha, Manel Haq, Halayna Lagova, and others.