 Abstract. Caudal regression syndrome is a rare anomaly that is characterized by impaired development of the lower half of the body. This includes absent or abnormal development of lumbar and sacrocoxigial segments. Other associations of this disease include abnormalities of genitourinary tract, gastrointestinal tract, and cardiopulmonary system. The exact etiology is unknown and is believed to be multifactorial but maternal diabetes is significantly linked to this rare disorder. We report the case of a newborn baby boy with caudal regression syndrome, hyperbilarubinemia, and patent ductus arteriosus. Keywords, caudal regression syndrome, CRS, caudal dysplasia, sacral agenesis, patent ductus arteriosus, PDA. This article was authored by Syed Muslehmedi, Usman Beg, Muhammad Hamzazia, and others.