 All right, our anchor speaker is here, Dr. Xu Chen. Dr. Chen is a National Medal of Science Laureate. He's the director of the Institute of Engineering and Medicine at UC San Diego. And if you were with us last night, he's one of the honorary founding fathers of the NIVIB legislation. And he'll summarize his thoughts about the conference. Thank you. Who's here? Thank you very much, Steve. It's my great pleasure, privilege, and honor to be here and to give some concluding remarks. The first thing I'd like to say is warmest congratulations to you, Rod, Dr. Pettigrew, and everyone in the National Institute of Biomedical Imaging and Bioengineering for your outstanding work in the Institute and for the community and for the patients. This is truly remarkable. It's only 10 years old. It's not even a teenager. But what you have done is so mature and so accomplished and influence so far reaching. It's really beyond belief. It's really remarkable. And also, today's program, the 10th anniversary celebration is wonderful indeed. First, we have lectures on innovation for health. Dr. Francis Collins, Dr. Phil Sharp, Dr. Chuck Vest, and the last lecture by Dr. Horacek. These are all visionary lectures from the current to the future, like the last lecture, and from the national level to the global level. So it really covers a lot of ground for us to think about. And it's very stimulating. And then we have outstanding lectures on various innovative technologies, such as Dr. Roger Tien's lecture on surgery through molecular fluorescence imaging. Dr. Carol Pugh's lecture on use of sensors and simulation to quantify clinical palpation. And Dr. Harry Shraff's lecture on high spatial and temporal resolution imaging. And then we have the two very moving stories from our patients, Mr. Summers and Mr. Casano. Then also videos that we saw on innovation, discovery, and health, and their technology showcases, which I will not read because it's in the program, except to say that the impacts on a lot of diseases, including influenza, cancer, cardiovascular disease, of the neurological diseases, and neurological diseases, and beyond. So it's really a marvelous program today. I personally learned a great deal and have a lot to think about the future. Now Dr. Sharpe mentioned about the three revolutions. When I give a lecture on the perspectives in biomedical engineering, I like to show these slides, which are exactly the same as what Dr. Sharpe says about almost 60 years ago, the double helix was a big breakthrough in biology. And then at the turn of the century, the sequencing of the human genome. As a result, we get such a vast amount of data and information that necessitates the integrative approach to biomedical sciences and engineering. Now this includes the integration of biology, medicine, and engineering, integration across different levels in the biological hierarchy and integration of education research technology and translation. I'll use one slide each to illustrate this. This is to illustrate that biology, medicine, and engineering need to be integrated together for the improvement of human health. Of course, the ultimate purpose is to improve the health of people and combat disease. In terms of biological hierarchy, we go from genes to molecules to cells, tissues, organs, and systems. Of course, genes and systems are interrelated as well. So we have this whole series of different scales, but they are all interrelated. We need to take an integrative approach to understand the whole system from every level on up. Now we need a cooperation not only between academia, clinical medicine, and industry, but also the society, government, and the foundations. So we need to all work together in order to improve people's health. So in this regard, N-I-B-I-B plays a very important role. And it not only works with academia, medical community, and industry, as well as foundation, and the society. So really it is playing a very major role in improving people's health. And N-I-B-I-B was formed 10 years ago. It was exactly when the Second Revolution had just happened. So it was very timely that it has the mission to improve human health by leading the development, accelerating the application of biomedical technologies. And it's committed to integrate physical and engineering sciences with the life sciences. It was stated from the very beginning to advance basic research and medical care and the vision is to change healthcare. It will push the frontier to make this a reality. And I'd like to show a few slides how N-I-B-I-B has fostered a career of young and established investigators. We just heard a lecture by Dr. Roger Tien. He repeatedly mentioned this Dr. Nuan Chun, who is actually a surgeon. And I'd just like to say here that as a surgeon, specialized ear disease and skull tumors, she received a Mentor Clinical Scientist Research Career Development Award, KO-8, from the N-I-B-I-B. So she will have time to be trained by Dr. Roger Tien in the techniques that you heard. And she developed this imaging technique which you saw in Dr. Roger Tien's slide to allow her to distinguish the tumor tissue from the nerves so that they can do surgery very clearly on the tumor to remove it as completely as possible without injuring the nerves. So this is a really remarkable achievement fostered by N-I-B-I-B. She also received R01 and also the new investigator award. And this is Dr. Dalin Tang, who was trained as a mathematician and as a mathematician, he said that this is the first R01 he received in 2004 and that enabled him to work with medical doctors, engineers and radiologists to lead to the formation development of this index, computation of plaque vulnerability index so that he can show how vulnerable the plaque in the artery is. And he said this is all due to the fact that he was supported by the N-I-B-I-B. Dr. Govalo of Georgia Tech, he also was trained in engineering primarily and the N-I-B-I-B allowed him to push forward his research on neuroscience and assistive technologies. And as a result, he was able to work with clinical experts, get his tenure and work on new areas such as speech and language pathology, some of his results are shown here. And the last one I'd like to show is Dr. Dennis Disher. He is a more established investigator and he received the N-I-B-I-B grant to allow him to develop this very novel concept that the extracellular matrix elasticity can modulate the stem cell differentiation on the hard tissue, such a hard matrix such as greater than 30 kilopascal, you would tend to have bone development as shown by the marker here. And for the soft ones, it would develop neural like marker and intermediate one would be muscle. And this has become a very important paper that formed the foundation of a lot of studies in this area, a huge impact and led to his election to the National Academy of Engineering their paper in cell in 2006 has been cited more than 2000 times in less than six years and is one of the five most cited papers in cell. So this is really remarkable. And he also trained Dr. Engler who was the first author as a graduate student. Now he is a faculty at UCSD. So this also allowed the training. So all of these really show how the NIBIB has not only foster research but also research training. As I look at the NIBIB funding, this is what I gathered from the website, it may be wrong, but my sense that it has not really increased that much from 2003 which is about 270 million to today about 320. Considering the inflation factor as Dr. Francis Collins mentioned, the real dollar actually has decreased. It's truly remarkable with this kind of limited resources the NIBIB can achieve so much in research and research training. And if we had more funds for NIBIB what can be achieved is even going to be much, much more. Now what NIBIB has done is on the one hand foster fundamental research. On the other hand, it's translation to clinical application and industrial products. And this is the goal for innovation for health. So again, I go back to the slide I showed before how NIBIB has worked with all these sectors to achieve the purpose, the function of cooperation and integration. Its achievement is truly remarkable. It's, and in the future I can see it's going to be even much, much, much more so. So at this 10th anniversary, I'd like to express my warmest wishes for a happy anniversary to NIBIB, a decade of innovation health, amazing innovations, discoveries and contributions to health. Warmest congratulations, most sincere thanks, all best wishes for a marvelous future for NIBIB. Thank you very much.