 This study found that certain microRNAs, mRNAs, can be used as biomarkers for the early detection of type II diabetes, T2D. The study identified nine mRNAs which were significantly increased in the serum of newly diagnosed T2D patients when compared to those with impaired fasting glucose, IFG, suggesting they may play a role in the progression from prediabetes to T2D. Additionally, bioinformatics and computational analysis predicted that one of these mRNAs, HSA-MIR 1225-3P interacts with two genes associated with T2D, MAP3K1 and HMGA1, providing further evidence of its potential role in the development of T2D. This article was authored by Marta Greco, Maria Mirabelli, Alessandro Salatino, and others.