 Activin A is a protein found in many types of cancer, including pancreatic ductal adenocarcinoma, PDAC. It has been shown to promote tumor growth and metastasis, as well as cause catechia, or weight loss. Researchers have now demonstrated that targeting this protein with specific RNA interference, CERNA, can reduce tumor size and improve survival in mice with PDAC. This suggests that blocking Activin A could be a viable treatment option for PDAC.