 The Sentinel-2A multispectral instrument, MSI, has proven to be a valuable tool for geological remote sensing applications. It has been successfully used to detect minerals associated with the hydrothermal alteration system in southeast Spain. The results obtained with Sentinel-2AMSI were found to be highly correlated with those obtained using Landsat-8 operational land imager, OLI, and a simulated Sentinel-2AMSI dataset. Additionally, the resulting maps produced by Sentinel-2AMSI corresponded well with the conceptual geologic model of the epithermal deposit. This article was authored by Harold van der Werf and Freik van der Meer.