 This review describes the current state of knowledge on the use of naturally occurring compounds from plants, known as phytochemicals, in cancer therapy. These compounds often act by regulating molecular pathways involved in cancer growth and progression, such as increasing antioxidant status, carcinogen inactivation, inhibiting proliferation, inducing cell cycle arrest and apoptosis, and regulating the immune system. The authors emphasize the potential drugability of phytochemicals and highlight recent trends and gaps in phytochemical-based anti-cancer drug discovery. This article was authored by Amit S. Jodhari, Pulavisi Mandave, Manasi Deshpande, and others.