 This pharmacokinetic study investigated the effect of EGFR on the PK-slash-PD targets for three antibiotics used as prophylactic treatment during cardiac surgery with extracorporeal circulation, ECC, support. The results showed that EGFR was the most important determinant of achieving the desired PK-slash-PD target for ampicillin or cephasolin, while body weight was the most significant factor for ciprofloxacin. This study provides valuable information regarding the optimal dosage of these antibiotics for different patient groups. This article was authored by Petrus Antevi, Vengela Kubikova, Martin Sema, and others.