 A study develops a unique antifungal micropillar titanium surface pattern that demonstrates both fungicidal and fungi static activity, persistently deterring biofilm formation by candida albicans and multi-drug resistant candida oris fungi for up to seven days. The T micropillars of 3.5 m height are fabricated using maskless, inductively coupled plasma reactive ion etching, killing approximately 50% of candida SPP. Irreversibly attached cells and preventing the proliferation of the cells by inducing programmed cell death. Proteomic analysis reveals that candida cells undergo extensive metabolic stress, preventing the transformation from yeast to the filamentous slash hyphal cell phenotype that is essential for establishing a typical in vitro biofilm. The mechanical stress imparted following interaction with the micropillars injures attaching cells and induces apoptosis whereby the candida cells are unable to be revived in a non-stress environment, shedding new insight toward the design of durable antifungal surfaces that prevent biofilm formation by pathogenic, multi-drug resistant yeasts. This article was authored by Fouk H. Loh, Denver P. Linklater, Arturo Abortomedina, and others. We are article.tv, links in the description below.