 The study reveals that ORI1 and ORI2 are crucial components of CIC channels in group 2 innate lymphoid cells, ILC2S, which play a significant role in the induction of type 2 inflammation. Blocking or genetic ablation of these channels down regulates ILC2 effector function and cytokine production, leading to amelioration of airway inflammation in multiple murine models. The study also confirms its findings in human ILC2S, suggesting potential insights into the development of therapies for allergic and atopic inflammatory diseases. This article was authored by Emily Howard, Benjamin P. Harrell, Dume Georges Helu, and others.