 The purpose of this study was to evaluate the effectiveness of two different approaches to science cafes in increasing perceptions of health and science literacy among participants. The first approach focused on genomic sciences while the second focused on health sciences. The results indicated that the genomic science cafe approach had a greater impact on perceptions of health and science literacy than the health science cafe approach. Additionally, regression analysis revealed that socioeconomic status and educational attainment were significant predictors of perceptions of health and science literacy. These findings provide insight into how to optimize the dissemination of research findings to the public in order to improve community health and well-being. This article was authored by Syed M Ahmed, M.I.A. Defino, Emily Conniss, and others.