 Science in general of all fields. I would love more collaboration between different disciplines because if you look at health, it's All disciplines apply physics applies biology applies chemistry applies Yeah, that's what like we're hoping. Yeah. Those guys are gonna come in and solve a data aggregation I'm like, okay. Well, here's a minute analysis of all the studies done on human health within biology Here's a minute analysis on like physics mental acid on like chemistry and like is there patterns or connections that we can see? Hopefully. Yeah. Yeah, I mean there are a lot of people from other areas are coming into biology For some reason a lot of computer scientists a lot of physicists It seems that like maybe people at some point get struck with like realization that what's limiting their Potential output like in physics or math or computers is the fact that they have a very limited lifespan And they're like, okay, wait, this is a problem I should fix and then I have a hundred years to do whatever I want like and you know Understanding physics of the universe or writing the like the the next cool I don't know computer thing and a lot of people are coming in and trying to understand Why is it that we age and why hasn't really been solved because it just seems like it's it's not that like Crazy a problem to solve is just biology. We've been looking and solving biological problems for I don't know already like a hundred years At least I mean just like the same level of skill or tool sets that we have I'm not saying like even because you know, they've been doing a lot of surgeries even in prehistoric times But it's just that we haven't really moved on aging on understanding the mechanism of aging for so long and people are outside of Biology are wondering what what's what's wrong with that's like or what's wrong with the scientists Why can't they figure it out? It just seems that you know, we have all the tools We can sequence the genome. We can understand cells even sometimes like in Real time we can look inside the cells and see what's going on But for some reason we just can't tie it back to this this kind of overall Process of aging and why does it occur and yeah, hopefully like this will get solved in a very short like in our lifetime Like very short time spent maybe even like within the next 20 years will have a much much better understanding That will result in you know, meaningful Life extension and therapies that can give us like decades of life Maybe even hundreds of years because that's like this is really what we're after We don't want to live just like five years long longer because that's not interesting And we don't want to live longer being you know old and decrepit We want to be as young as as healthy as active as possible for as long as possible I mean, this is the this is the goal. It'd be interesting how people respond with the implications to society Well, I mean It's definitely I think it would be just much better society in general much more fun Less suffering because right now the suffering is isn't visible We don't really see people, you know with cancer or people who are in retirement homes We kind of like put them away and just close our eyes We don't want to look at them having a very tough time because you know The last few years of their lives are not pleasant But if you know, there's there is no more suffering or there's much less suffering from those things You know right now I think it's a number one source of suffering in the world is aging like people They every day wake up in pain and you know, or even people like with cancer They're much younger people But when they come to the realization that they only have like I don't know five years left to live or three years left to live and It's just that the mental you know toll and the mental suffering that they have is It's so indescribable and I think just this When society realizes this that there's a lot of things that Go on behind the scenes that we don't see that we should fix I think that much more support for doing, you know, everything we can to to get rid of aging Yes, as quickly as possible. We'll be done. Have you seen anything else besides it the Yakumoto factors anything? I mean, there's yeah, there's a bunch of other approaches That are potentially very interesting. There's We briefly talked about this retro elements in our genome like the ancient viruses that that said dormant for a long time but for some reason those retro viruses Get activated after like age 45 and they start like little by little keep being expressed in cells and then Jumping back into the into the DNA like that's what they do that's better like the jumping genes they're called and for you know for like 45 to 50 years the Dormant and after that they you know start being active and that's when cancer skyrockets so one of the ideas that maybe Cancer is caused by the activation of these genes So one of the ideas is to try to prevent these genes from being activated So all kinds of approaches are now being Considered to kind of prevent the these jumping genes from being as interesting So it probably happens like it's there's a trigger with the epigenic age Yes, and the viral knows the age marker seems that way. Yeah. Yeah. Yeah Yeah, it like it might not just like no, but yeah at some point it's like little by little gets Released from it's little jail and it's once it is free It starts to be active and kind of wreaking havoc and creating mutations And so yeah one of the approaches is the is called like inhibiting reverse transcriptase work It's one reverse transcriptase is one of the enzymes that is helping those jumping genes kind of jump back into DNA and It's now being studied in mice and in dogs and we're gonna see if it's gonna prolong lifespan in those animals And if you know that's effective We're gonna try to not we but like scientists are gonna try to see if that approach works in humans It's it's quite promising in my mind as well because the cancer is like Like it's number two killer in terms of aging I mean heart disease is number one like heart disease is a category including stroke and like cardiovascular stuff Heart disease, but cancer is like a close second and in terms of suffering I think it might be even like worse than heart disease because you know, you Well, you don't want to have to pick which kind of suffering you have Ideally you wouldn't want either of those but yeah, I mean cancer is a is a big component of age-related deaths and so if we can decrease that by inhibiting jumping genes that We already gonna have like small victories. So most likely they're realistically It's gonna be a multifactorial Approach sure whether it's this or Yamanaka or in stem cells either or but it's gonna be many different therapies as opposed to go This is a holy grail Yeah, it could be or I mean I hate be great if there's just one thing you kind of turn on the like Yamanaka factors for a Little bit and they completely rejuvenate you and you don't have to do this for another like two decades That's what David Sinclair preach there now. He's like, okay We're gonna insert these genes in you and then you're gonna take these doxycycline the science abiotic that Activates those genes you're gonna do it like every every other decade and I mean, that's that's the that's the goal That'd be great But yeah, I mean right now we we shouldn't for sure rule out any other approaches because we don't know who's gonna You know or which parts of the puzzle who's gonna develop and not just those But there's a lot of therapies being created where they kind of repair the damage that already occurred Yeah, there's like cross links and in our collagen was champion that to repair like mechanic Yeah, that's right. Yeah. Yeah, the Aubrey de Grey the sense approach this strategy is for engineered negligible. So I don't have a donation to them. Yeah. Yeah. Oh, yeah. Yeah. Yeah, he did he donated like two and a half billion a billion in Bitcoin two cents and also I think Michael Antonoff of Oculus Cuz they're correct me if around their thesis is more kind of like a car mechanic thesis absolutely Yeah, they're not about program like of aging at all build a new piece and put it in. Yeah, they're like saying yeah We're no different from cars. We have metabolism that is creating damage So why don't we just without even knowing why this damage occurs? We don't want to know we just gonna we're gonna fix the damage and we believe it's gonna take care of aging That's the Aubrey de Grey approach And yeah, they have this the seven categories of different kinds of damage and they have projects working on fixing each one and some of the projects are already advanced enough to Turn into startups, but others are still kind of in the lab but yeah, and I mean although I have a differing view of how aging Works, I fully support their approach just because you know We're gonna need to clear damage or fix damage anyways And if they find ways to clear our like better amyloids or our cross links in a in our Extracellular matrix that that'd be great I mean why not you can use it in conjunction with others Therapies or maybe stem cell therapies and that's actually another thing that we didn't touch upon in terms of like what people can do today some people are doing some cell therapies and Like anecdotally a lot of people are swearing by them. I have friends of mine And they love it. Yeah, and and and there's research like even in done properly It's just that mean the field of stem cell research is is a little bit Weird because a lot of it is done in like in secret or offshore zones because people first of all they don't want to like get go to jail if the you know Mess up legally sure and secondly, I don't know just historically it happened That they all kind of went offshore and they have no reason to publicize it if it works They have good clients who are you know paying them a lot of money different types of stem cell therapy Yeah, and that's the thing. Yeah, they get very different it all it's like a craft It's not it's not even at this point as so much as science is it really is a person if he knows what he's doing He found some kind of technology that he can maybe isolate the right stem cells or rejuvenate the cells in a way And then he knows how to you know inject them back into the patient in a certain way or a certain area is that You know produce benefits that the patient needs then, you know, that's what he's gonna do And he might not even not even want to publicize it if it's like a trade secret to him That's another thing that people are making money on on this and they have like a differing incentive from like the humanity Approach where you human or like human rights approach where like you should be doing it not to make money We should eradicate aging. Yeah, I mean to get rich is a secondary funny. So And that's like one of our things that we were we're saying we're saying mission first Yes, it's second and to us. It's much more important that we fix aging even if we you know Don't get a sense from this correct someone else does it which is gonna be just as happy. I agree