 The study of hydroxypropyl methylcellulose, HPMC, gels has become increasingly important due to their potential use in biomedical applications. In this paper, the authors investigate the effects of Hofmeister salts on the gelation of HPMC solutions. They also examine the effects of ionic and non-ionic surfactants on the gelation process. Additionally, they explore the swelling, dissolution, and dispersion of HPMC tablets in simulated body fluids. Finally, they provide explanations for the observed phenomena based on the chemical structure and molecular binding slash association of HPMC in a medium. This article was authored by Sunil C. Joshi.