 Highlight's periplaneter americana-elf derived exosome-like nanoparticles, PALNS, as a novel wound healing accelerator was isolated and proved. Protein and small RNA components in PALNS were characterized by omics technology. PALNS remarkably accelerated diabetic wound healing and were involved in anti-inflammatory, re-epithelialization and autophagy regulation in this process. This article was authored by Chen Liao, Li Junsu, Lan Pang, and others.