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Multiplex Innate Cytokine Signal Analysis of Brain Function

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Published on Jun 13, 2013

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Dr Richard P. Kraig presents a webinar on the use of cytokine analysis in the investigation of normal brain function. Dr Kraig and his colleagues use the Bio-Plex® suspension array system to explore innate cytokine signaling activity in the brain, focusing on downstream gene activation and protein transcription and how the resulting phenotypes affect neural activity. They hope to better understand intrinsic neuroprotection mechanisms, with implications for the prevention and treatment of neurological diseases such as epilepsy and dementia.

Dr Kraig discusses some of the issues encountered during work in his laboratory using femtomolar-level cytokine analysis in a murine model to study how environmental factors influence learning and neuroprotection, and to determine the cellular and molecular processes involved. The sensitivity, reproducibility, and high dynamic range of Bio-Plex cell signaling assays enable these researchers to obtain precise measurements of cytokine levels and gain insight into this biological system.

Presenter: Richard P. Kraig, PhD
William D. Mable Professor in Neurosciences
University of Chicago Hospitals

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