 ATP synthase is an essential enzyme in all living organisms responsible for producing ATP from ADP. It is found in the inner membrane of mitochondria, chloroplasts, and bacteria, where it is involved in the production of energy. In recent years, researchers have discovered that certain compounds can inhibit ATP synthase, making them potential candidates for treating antibiotic-resistant bacteria. These compounds include animal venoms, resveratrol, venturicin and A, bedacoline, tomatidine, pisciotanil, oligomycin A and N, endicyclohexrobotamine. Each of these compounds targets ATP synthase differently, and when combined with antibiotics, they increase the susceptibility of pathogenic bacteria to antibiotics. This review summarizes the current state of knowledge on the use of these compounds as therapeutic agents against antibiotic-resistant bacteria. This article was authored by Ruan Maki, Nadia Albecker, Milena Kafori, and others. We're article.tv, links in the description below.