 This research has developed a novel approach combining photothermal therapy, PTT, and gene therapy to treat osteosarcoma. It involves using a two-dimensional FEPS3 nanoseat platform to deliver a microRNA inhibitor, MIR-19A, as well as a photothermal conversion agent. This combination allows for more effective treatment of osteosarcoma than either method alone. Additionally, the FEPS3 nano sheets are designed to degrade after treatment, reducing any potential side effects. This article was authored by Tingting Luo, Mingyang Jiang, Zixiang Cheng, and others.