 The study aimed to investigate the knowledge, attitude, and willingness toward the COVID-19 vaccine among medical and non-medical students from three universities in Zhejiang province. The results showed that medical students had higher awareness rates of the vaccine and approval rates for its safety and efficacy compared to non-medical students. Factors such as lower-class grades, rural origin, COVID-19 vaccine attitude, and health self-management influenced the acceptance of COVID-19 vaccination among medical students, while urban origin and COVID-19 vaccine attitude hindered non-medical students' willingness to be vaccinated. The study highlights the importance of accurate information dissemination and promoting health self-management to improve students' willingness to receive the COVID-19 vaccine. This article was authored by Lien G.A.O., Simon Su, Niu Niu Du, and others.