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Mutant mitochondrial protein locomotion

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Published on Mar 24, 2010

This pair of time-lapse movies show mitochondria moving along nerve cell fibers. In this clip, mitochondria with normal mitofusin proteins move quickly along the fiber. In the second clip, mitochondria with a mutant form of mitofusin 2 are smaller and move slowly. This abnormal movement is thought to be the basis for the neurodegenerative disease Charcot-Marie-Tooth type 2A.

Credit: Courtesy, with permission: Misko et al. The Journal of Neuroscience 2010.

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