 The study investigates the role of secreted frizzled-related protein 2, SFRP2, in rheumatoid arthritis, RA, model rats and its mechanisms on RA pathogenesis. It suggests that SFRP2 is down-regulated in RA model rats due to DNA methylation, and overexpression of SFRP2 suppresses the RA pathogenesis and WNT signaling in fibroblast-like, synovial cells, FLS, from RA model rats. Knockdown of SFRP2 has an opposite observation. Additionally, up-regulated missy P2 is involved in the SFRP2 regulation and pathogenesis of RA model rats, and missy P2 and DNMT1 have synergistic inhibition roles in the SFRP2 expression. The study suggests that combination of DNMT1 and DNA methylation may be a promising treatment strategy for individuals with RA in which SFRP2 is down-regulated. This article was authored by Cheng Guimiao, Zhen Chang, Jin Fengdu, and others. We are article.tv, links in the description below.